Andrew Huberman introduces the AMA segment and the purpose of the premium channel.

• This AMA is part of the premium subscriber channel to support the main podcast and research.
• Premium subscriptions contribute to research at Stanford and elsewhere, focusing on human health and performance.
• Subscribers can access the full episode, future episodes, and transcripts through the premium channel.

Huberman discusses resveratrol and its impact on lifespan, explaining why he takes grape seed extract.

• Resveratrol was once believed to extend lifespan by impacting cellular pathways but is now largely debunked in this regard.
• Huberman takes grape seed extract for vascular function and blood flow, not for lifespan extension.
• He invites the audience to share any recent studies that might show contrary evidence regarding resveratrol and longevity.

Huberman shares his personal regimen of NR and NMN supplements and his experience with NAD infusions.

• He takes NR and NMN not for lifespan extension but for mental and physical energy, and has no financial ties to companies selling these supplements.
• NAD infusions can be uncomfortable and expensive, but they provided him with improved energy and recovery post-illness.
• Huberman emphasizes his subjective experience with these supplements and their effects on his energy levels.

Huberman explains why he does not take metformin, berberine, or rapamycin.

• The current data does not justify taking metformin or berberine to increase lifespan, and berberine has given him headaches.
• Rapamycin is under investigation for extending lifespan in animals, but the side effect profile does not justify its use for him at this time.
• Huberman's decisions on supplements may change with future scientific data.

Huberman emphasizes foundational health practices over supplements for longevity and quality of life.

• Foundational practices like quality sleep, exercise, nutrition, stress management, and social connections are crucial for health and longevity.
• Supplements are secondary to these basic health practices and should be considered only after these are optimized.
• Always consult with a physician before adding or removing supplements or prescription drugs.