Zach Galifianakis interviews Jessica Chastain, discussing her Oscar-nominated role in Zero Dark Thirty and the presence of torture scenes in the film.

• Jessica Chastain discusses the importance of accuracy in Zero Dark Thirty.
• Zach jokingly asks if the movie is about Chris Brown, referencing the film's title.
• Jessica explains the importance of including torture scenes to reflect the true events of the Bin Laden capture.
• Zach humorously suggests that it would have been better to get the actual person who caught Bin Laden instead of an actress.

Sally Field talks about her experiences gaining weight for a role, her views on pennies, and her religious background.

• Sally Field gained 25 pounds for her role in a movie, jokingly asking if she ate Anne Hathaway.
• Zach inquires if Sally looks at pennies differently after acting in Lincoln, leading to her humorous dislike for them.
• Zach mistakenly assumes Sally Field is Jewish, but she clarifies she is Catholic.

Daniel Day-Lewis makes a silent appearance while Bradley Cooper discusses his Oscar nomination and acting career, ending with a mock Oscar acceptance speech.

• Daniel Day-Lewis is introduced but does not speak during his short appearance.
• Bradley Cooper talks about his Oscar nomination for Best Actor and his feelings of inclusion within the acting community.
• Zach presents Bradley with a mock Oscar acceptance speech, highlighting his supposed loss to Daniel Day-Lewis.
• The segment ends with a comedic argument about Zach's priorities between his show and his friendship with Bradley.

Zach conducts an awkward interview with Tila Tequila about her MySpace friends and jet skiing, followed by an uncomfortable interaction with Jennifer Aniston.

• Tila Tequila talks about having 3.6 million friends on MySpace and jokes about jet skiing around the world with Zach.
• Jennifer Aniston is asked to move a fern for Tila and experiences an awkward seat exchange.
• Zach and Jennifer discuss her work with Adam Sandler and her movie 'Just Go With It'.

Brad Pitt discusses his films, personal grooming habits, and charity work, with Zach delivering his signature awkward style of humor throughout the interview.

• Zach inquires about Brad Pitt's personal hygiene and his history of playing Nazi-hating characters.
• Brad Pitt explains his charity work with the Make It Right organization, which builds homes in the Lower Ninth Ward post-Katrina.
• Zach gives Brad Pitt a bassoon as a gift, a humorous nod to Pitt's fatherhood.

Jimmy Kimmel shares about his talk show career and personal life with Sarah Silverman, with Zach incorporating his usual offbeat humor.

• Jimmy Kimmel discusses what it's like to be a late-night talk show host and his childhood dream of joining the industry.
• Zach and Jimmy touch on Jimmy's relationship with Sarah Silverman and their comedic interactions at home.
• A mock commercial for bananas humorously interrupts the interview.