Conversation begins with the host questioning the guest's perspective on mTOR and IGF-1, which are often perceived as harmful.

• The host starts by questioning the guest's perspective on mTOR and IGF-1.
• The guest notes that many scientists do not understand the difference between a short-term response to a stressor versus dysregulated signaling that persists indefinitely.
• The guest explains that mTOR elevations leading to cancer mostly originate at insulin resistance.

Discussion on the relationship between resistance training, mTOR and IGF-1, and cancer incidence.

• The guest refers to findings from meta-analyses on cancer incidents amongst resistance trainers, showing lower levels of cancer in people who resistance train.
• He suggests that there is a difference between these two signals, and that resistance training does not increase mTOR to a detrimental extent.
• The guest asserts that tissue specificity also plays a crucial role in this context.

Discussion on the impact of overall diet quality, highlighting that good diet quality can be achieved on a variety of diets.

• The guest emphasizes the importance of overall diet quality and suggests that good diet quality can be achieved on a variety of diets, including ketogenic and plant-based diets.
• He notes that high levels of mTOR activation and IGF-1 are typically found in people with poor dietary habits.
• The guest clarifies that high protein diets do not necessarily lead to cancer, as seen in a study of 100,000 people.

The host concludes the podcast with some closing remarks and a disclaimer about the content of the podcast.

• The host ends the podcast reminding the listeners that the content is for general informational purposes only and not intended to be a substitute for professional medical advice.
• He also mentions that he maintains an active and up-to-date list of the companies he invests in or advises on his website.