Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis
Andrew Huberman
162 min, 13 sec
A comprehensive discussion on gut sensing, its mechanisms, and its influence on the brain and behavior.
Summary
- Gut sensing involves specialized neuroepithelial cells, termed neuropod cells, that detect food components and relay information to the brain.
- Neuropod cells respond to specific attributes of food, including macronutrients like amino acids, fats, and sugars, as well as micronutrients, temperature, and acidity.
- This gut-brain communication influences not only our digestion and food choices but also impacts emotions, behavior, and decision-making processes.
- Understanding the gut-brain axis can help us make better health-related decisions and may provide insight into conditions like obesity, diabetes, and mental health disorders.
Chapter 1
![Dr. Diego Bohórquez introduced as a guest on the Huberman Lab podcast, discussing his expertise in gut sensing.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE0LCJwdXIiOiJibG9iX2lkIn19--91e2b192cbe7229f6182a28adb9a7da5731f5162/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_203.jpg)
Dr. Diego Bohórquez introduced as a guest on the Huberman Lab podcast, discussing his expertise in gut sensing.
- Dr. Diego Bohórquez is a professor of medicine and neurobiology at Duke University, specializing in gut sensing or the gut-brain axis.
- His unique background in gastrointestinal physiology, nutrition, and neuroscience positions him as a pioneer in understanding how the gut communicates with the brain.
- The conversation aims to explore aspects of gut sensing, from the neurons involved to its impact on our behavior and emotions.
![Dr. Diego Bohórquez introduced as a guest on the Huberman Lab podcast, discussing his expertise in gut sensing.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE0LCJwdXIiOiJibG9iX2lkIn19--91e2b192cbe7229f6182a28adb9a7da5731f5162/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_203.jpg)
Chapter 2
![Joovv's medical-grade red light therapy devices are discussed, highlighting their health benefits.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE0LCJwdXIiOiJibG9iX2lkIn19--91e2b192cbe7229f6182a28adb9a7da5731f5162/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_203.jpg)
Joovv's medical-grade red light therapy devices are discussed, highlighting their health benefits.
- Joovv offers medical-grade red light therapy devices that use clinically effective wavelengths for health benefits.
- Red and near-infrared light can improve cellular health, muscle recovery, skin health, reduce pain, enhance sleep, and more.
- The handheld juv Go unit is particularly mentioned for its convenience and effectiveness.
![Joovv's medical-grade red light therapy devices are discussed, highlighting their health benefits.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE0LCJwdXIiOiJibG9iX2lkIn19--91e2b192cbe7229f6182a28adb9a7da5731f5162/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_203.jpg)
Chapter 3
![LMNT is introduced as an electrolyte drink sponsor, offering hydration and electrolyte balance.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE3LCJwdXIiOiJibG9iX2lkIn19--20acabdb844d09e80af6027927bbd6712097a785/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_279.jpg)
LMNT is introduced as an electrolyte drink sponsor, offering hydration and electrolyte balance.
- LMNT is an electrolyte drink that provides essential elements like sodium, magnesium, and potassium.
- Proper hydration and electrolyte balance are crucial for optimal brain and body functioning.
- LMNT is sugar-free and helps avoid dehydration effects on cognitive and physical performance.
![LMNT is introduced as an electrolyte drink sponsor, offering hydration and electrolyte balance.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE3LCJwdXIiOiJibG9iX2lkIn19--20acabdb844d09e80af6027927bbd6712097a785/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_279.jpg)
Chapter 4
![Helix Sleep is recognized for their customized mattresses aimed at improving sleep quality.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE5LCJwdXIiOiJibG9iX2lkIn19--3241cf90794061ed98c680b9cb7187f7b7dfaf99/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_367.jpg)
Helix Sleep is recognized for their customized mattresses aimed at improving sleep quality.
- Helix Sleep offers customized mattresses based on individual sleep preferences for improved mental and physical health.
- A quiz matches customers to the ideal mattress, and the company currently has a Memorial Day offer for discounts and free pillows.
![Helix Sleep is recognized for their customized mattresses aimed at improving sleep quality.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjE5LCJwdXIiOiJibG9iX2lkIn19--3241cf90794061ed98c680b9cb7187f7b7dfaf99/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_367.jpg)
Chapter 5
![Dr. Bohórquez shares his background, growing up in the Amazon and his path to studying the gut-brain axis.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Dr. Bohórquez shares his background, growing up in the Amazon and his path to studying the gut-brain axis.
- Dr. Bohórquez grew up in the Amazon, which shaped his interest in the natural world and its influence on human physiology.
- His studies in agriculture and later nutrition led to a fascination with the gut and its complex role in overall health.
- A pivotal moment in his academic journey was the realization of the gut's deep connection to brain function and behavior.
![Dr. Bohórquez shares his background, growing up in the Amazon and his path to studying the gut-brain axis.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 6
![Neuropod cells are explained as the sensory system of the gut, detecting food components and signaling the brain.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Neuropod cells are explained as the sensory system of the gut, detecting food components and signaling the brain.
- Neuropod cells are specialized cells in the gut that detect and respond to the food we consume.
- They are involved in sensing various food components such as amino acids, fats, sugars, temperature, and pH levels.
- Neuropod cells communicate with the brain, influencing emotions, behavior, and decision-making, often below our conscious awareness.
![Neuropod cells are explained as the sensory system of the gut, detecting food components and signaling the brain.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 7
![The influence of gut-brain communication on food choices and cravings is explored.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
The influence of gut-brain communication on food choices and cravings is explored.
- The gut-brain axis affects immediate food choices, like preferring sugar over non-caloric sweeteners.
- Neuropod cells' activation can modify cravings and appetite, even for plain water, when associated with specific food experiences.
- The gut's signals to the brain can impact our perception and enjoyment of food, driving us to seek out certain tastes and textures.
![The influence of gut-brain communication on food choices and cravings is explored.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 8
![Traditional and cultural practices of consuming and sharing food are discussed in relation to gut sensing.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Traditional and cultural practices of consuming and sharing food are discussed in relation to gut sensing.
- Cultural practices around food, such as sharing meals and discussing community issues, are tied to gut sensing and bonding.
- The consumption of certain traditional foods, like guayusa, in communal settings can influence energy levels and social dynamics.
- Understanding traditional relationships with food can offer insights into how food choices have evolved and their impact on health and community.
![Traditional and cultural practices of consuming and sharing food are discussed in relation to gut sensing.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 9
![Plants' role in health and medicine is examined, including their use in traditional practices and modern research.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Plants' role in health and medicine is examined, including their use in traditional practices and modern research.
- Plants have historically been a primary source of medicine, with many modern drugs derived from plant compounds.
- Traditional practices often view plants as teachers, with intricate knowledge of their environment and therapeutic properties.
- Current scientific interest in plant-based psychedelics and other botanicals reflects an ongoing exploration of plants' medicinal potential.
![Plants' role in health and medicine is examined, including their use in traditional practices and modern research.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 10
![The concept of gut intuition is discussed, considering how subconscious gut sensations can influence cognition and behavior.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
The concept of gut intuition is discussed, considering how subconscious gut sensations can influence cognition and behavior.
- Gut sensations provide a form of intuition that can guide decision-making and emotional responses, often beyond conscious thought.
- Shared food experiences may enhance social bonding and influence business and personal relationships through common gut responses.
- The gut's impact on subconscious feelings and 'gut feelings' is an area ripe for future exploration, connecting biology and psychology.
![The concept of gut intuition is discussed, considering how subconscious gut sensations can influence cognition and behavior.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Chapter 11
![Final thoughts on the gut's influence on human experience are shared, along with acknowledgments.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
Final thoughts on the gut's influence on human experience are shared, along with acknowledgments.
- The gut's influence on human experience extends beyond food to encompass feelings, relationships, and cultural practices.
- Acknowledgments are given to those who have supported Dr. Bohórquez's journey, including his team, mentors, and academic institutions.
- The conversation underscores the importance of continued research and dialogue about the gut-brain axis and its impact on our lives.
![Final thoughts on the gut's influence on human experience are shared, along with acknowledgments.](https://www.videogist.co/rails/active_storage/representations/redirect/eyJfcmFpbHMiOnsiZGF0YSI6MTg4MjI2LCJwdXIiOiJibG9iX2lkIn19--fa176f2dadb1c7accb919b2875833ff274faa83a/eyJfcmFpbHMiOnsiZGF0YSI6eyJmb3JtYXQiOiJqcGciLCJyZXNpemVfdG9fbGltaXQiOls3MjAsbnVsbF19LCJwdXIiOiJ2YXJpYXRpb24ifX0=--c9426325207613fdd890ee7713353fad711030c7/11088_1470.jpg)
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