Introduction to the Huberman Lab Podcast and guest Dr. Peter Attia.

• Andrew Huberman introduces the podcast and highlights its focus on science and science-based tools for everyday life.
• He introduces Dr. Peter Attia as a medical doctor trained at Stanford University School of Medicine and Johns Hopkins School of Medicine.
• Dr. Attia is presented as a trusted voice on the topics of healthspan and lifespan, known for his systematic review of research and clinical trials.

Huberman and Dr. Attia discuss the NAD pathway and its significance.

• The conversation focuses on the NAD pathway, which has gained attention as a potential target for improving lifespan.
• Different approaches to increasing NAD levels are explored, including taking NR, NMN, direct infusions, or orally taking NAD.
• Dr. Attia and Huberman compare different molecules and their efficacy for longevity or health span.

Dr. Attia and Huberman discuss their personal supplement regimens.

• Both discuss their own supplement regimens, reflecting their beliefs on what could potentially affect healthspan and lifespan.
• They go through what they take and why, including supplements that they believe may be useful and others that they think may not be.

Huberman provides disclaimers for the podcast and thanks sponsors.

• Huberman emphasizes the podcast's role in bringing zero-cost science information to the public.
• He thanks the podcast's sponsors, highlighting products from Element, Levels, and Eight Sleep.

In-depth discussion on NAD pathway and strategies for longevity.

• The discussion delves into details about NAD and its biological pathway, including the delivery routes and supplements.
• They touch on topics like rapamycin, metformin, fasting, and genomics as part of the longevity framework.
• Huberman and Dr. Attia emphasize the importance of understanding these concepts to make informed decisions about supplements and approaches to longevity.

Concluding thoughts on NAD, supplements, and lifestyle choices.

• Dr. Attia and Huberman conclude that lifestyle factors are more significant than supplements for healthspan and lifespan.
• Huberman shares his supplement routine and how it complements his lifestyle choices.
• They both agree that while some supplements might have positive effects, they are not a substitute for essential lifestyle practices.